Volume 1 of The Complete Sherlock Holmes begins with Holmes's first appearance, A Study in Scarlet, a chilling murder novel complete with bloodstained walls and cryptic clues. This is followed by the baffling The Sign of Four, which introduces Holmes's cocaine problem and Watson's future wife. Volume I also includes the story collections The Adventures of Sherlock Holmes and The Memoirs of Sherlock Holmes and concludes with the tale "The Final Problem," in which Conan Doyle, tired of writing Holmes stories, kills off his famed sleuth.