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A dazzling tale of science and ritual, terror and love, STATE OF WONDER is the most ambitious and mesmeric book yet from the Orange prize-winning author of Bel Canto. Heart of Darkness meets The Poisonwood Bible by way of Oscar and Lucinda in this shimmering, explosive and highly cinematic tour de force. Set on the banks of the Brazilian Rio Negro among the remotest of tribes where medical science and ancient secrets collide and combine in a way that could transform the lives of women forever.