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Is inheritable genetic modification the new dividing line in gene therapy? The editors of this searching investigation have established a distinguished team of scientists and scholars to address the issues from the perspectives of biological and social science, law and ethics. They consider how society might deal with the ethical concerns raised by inheritable genetic modification, and re-examine prevailing views about whether these procedures will ever be ethically and socially justifiable. This is an essential contribution to one of the critical debates in current genetics.