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This extensively updated fourth edition expands the discussion of FHIR (Fast Health Interoperability Resources), which has rapidly become the most important health interoperability standard globally. FHIR can be implemented at a fraction of the price of existing alternatives and is well suited for use in mobile phone apps, cloud communications and electronic health records. FHIR combines the best features of HL7's v2, v3 and CDA while leveraging the latest web standards and clinical terminologies, with a tight focus on implementation.