Receptors: Models for Binding, Trafficking, and Signaling: Models for Binding, Trafficking and Signalling

Receptors: Models for Binding, Trafficking, and
Signaling bridges the gap between chemical engineering and
cell biology by lucidly and practically demonstrating how a
mathematical modeling approach combined with quantitative
experiments can provide enhanced understanding of cell
phenomena involving receptor/ligand interactions. In
stressing the need for a quantitative understanding of how
receptor-mediated cell functions depend on receptor and
ligand properties, the book offers comprehensive treatments
of both basic and state-of-the-art model frameworks that
span the entire spectrum of receptor processes--from
fundamental cell surface binding, intracellular trafficking,
and signal transduction events to the cell behavioral
functions they govern, including proliferation, adhesion,
and migration. The book emphasizes mechanistic models that
are accessible to experimental testing and includes detailed
examples of important contemporary issues. This much-needed
book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell
biologists with the insights that can be gained from
engineering analysis and synthesis. As such, chemical
engineers, researchers, and advanced students in the fields
of biotechnology, biomedical sciences, bioengineering, and
molecular cell biology will find this book to be
conceptually rich, timely, and useful.