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"With examples based on the authors' 30 years of real-world experience in many areas of clinical drug development, this book provides a thorough presentation of clinical trial methodology. It presents detailed step-by-step illustrations on the implementation of the open-source software R. Case studies demonstrate how to select the appropriate clinical trial data. The authors introduce the corresponding biostatistical analysis methods, followed by the step-by-step data analysis using R. They also offer the R program for download, along with other essential data, on their website"--Provided by publisher.